Dinosaur Syndrome Revisited

The Dinosaur Syndrome Revisited:  Big Body, Little Brain, Become Extinct

Over the last decade there is growing evidence that shows the harmful effects of too much fat on your body. In a study of 1,438 Japanese men, researchers found significant decreases in brain size in the PFC and temporal lobes (learning and memory). Nora Volkow, director of the National Institute on Drug abuse, and colleagues found that in healthy adults a high BMI (body max index) was inversely correlated with activity in the PFC. Elevated BMI has also been associated with myelin abnormalities in the PFC of healthy normal and elderly adults.

The goal of our study was the test the hypothesis that an elevated BMI is associated with lower blood flow to the PFC in a healthy group of people on brain SPECT imaging. To that end, we compared our group of “healthy” subjects who had a high BMI with people in our “healthy” group of normal weight. The results of our study were very clear. The high BMI group had statistically significant lower activity in the PFC compared with the normal group.

Obesity is becoming a worldwide epidemic and is a risk factor for many chronic condition, including cardiovascular disease, depression, and neurodegenerative diseases like Parkinson's and Alzheimer's. It has recently found to be worse for your liver than alcoholism.

We were not able to determine if problems in the PFC led to increased impulsivity and subsequent obesity or if being overweight or obese directly caused brain changes. Both scenarios may be true. The fact that we used a healthy-brain group and specifically excluded ADHD or other behavioural disorders argues against the premorbid hypothesis, but other studies have shown an association between ADHD and obesity. Still other authors report that fat tissue directly increases inflammatory chemicals, which likely have a negative effect on brain structure and function.

One of the major problems with being overweight or obese is that there is evidence that it damages your PFC, which we know is the major decision-making part of the brain. So if you do not get your weight under-control, it will become harder and harder to use get your own good judgment over time to get and stay healthy. Now is the time to start enhancing your health and longetivity, not at some arbitrary point in the future, which most likely will never come.

The Day of the Flowers. Photo by Elena.

ADHD, PFC Problems, and Early Death

ADHD is associated with low activity in the PFC. Initially, ADHD was thought of as a childhood disorder that most kids outgrew by the time they turned twelve or thirteen. The hallmark symptoms of ADHD are short attention span, being easily distracted, disorganization, hyperactivity (trouble sitting still), and poor impulse control. People with ADHD, like Jose, often exhibit excitement-seeking or conflict-seeking behavior; they also tend to have trouble with time (they are often late and turn in assignments at the last minute). Over the last three decades it has become clear that many ADHD children continue to have debilitating symptoms for the rest of their lives. They tend to outgrow the physical hyperactivity but not the problems with disorganization, inattention, distractibility, and impulse control. Untreated ADHD has been associated with a higher incidence of:

• Drug and alcohol abuse (impulsivity and to calm feelings of hyperactivity)
• Relationship problems (impulsivity and conflict seeking)
• School failure (attentional problems and impulsivity)
• Job-related problems (problems with time, attention, and impulse control)
• Medical problems (associated with chronic stress, plus more head trauma with the excitement-seeking behavior)
• Obesity (lack of impulse control)
• Depression (chronic failure)
• Lack of conscientiousness (all of the above).

In the book Daniel G. Amen wrote with noted neurologist Rod Shankle, “Preventing Alzheimer's, the authors argued that ADHD is likely associated with Alzheimer's disease because of its connection with many of the illnesses that put people at risk for it, such as alcohol abuse, obesity, depression and head trauma. This is very important, because when ADHD goes untreated, a person will not be able to control his or her impulses, setting him up for significant health problems, poor decisions, and earlier death. If you or someone you love has symptoms of ADHD, it is important to be treated. Natural ways to treat ADHD include intense aerobic exercise, a very healthy diet, a multivitamin, fish oil, and supplements (such as green tea, rhodiola, L-Tyrosine) or medication (such as Ritalin or Adderall) to enhance PFC function.

Once you realize the absolutely critical role of the PFC to longevity, you then need to do everything possible to protect it and rehabilitate it if necessary.

(Use Your Brain by Daniel G. Amen, M.D. Excerpt).

Way to healthy live. Photo by Elena.